Vagus nerve stimulation therapy, epilepsy, and device parameters
2002; Lippincott Williams & Wilkins; Volume: 59; Issue: 6_suppl_4 Linguagem: Inglês
10.1212/wnl.59.6_suppl_4.s31
ISSN1526-632X
AutoresChristi Heck, Sandra L. Helmers, Christopher M. DeGiorgio,
Tópico(s)Neuroscience and Neural Engineering
ResumoOur understanding of a precise dose-response relationship for vagus nerve stimulation (VNS) therapy in the treatment of seizures is still evolving. Because several parameters are involved in VNS therapy, the individual contribution of each is not well understood. This review discusses the efficacy of stimulation parameters used in the VNS clinical trials. The background, influence on safety and efficacy, and role in helping to achieve seizure control are discussed for each VNS device parameter: output current, pulse duration, frequency, and duty cycle. Finally, we provide an algorithm for the adjustment of VNS device settings (see Appendices).
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