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CAVERNOSAL EXPANDABILITY IS AN ERECTILE TISSUE MECHANICAL PROPERTY WHICH PREDICTS TRABECULAR HISTOLOGY IN AN ANIMAL MODEL OF VASCULOGENIC ERECTILE DYSFUNCTION

1998; Lippincott Williams & Wilkins; Volume: 159; Issue: 6 Linguagem: Inglês

10.1016/s0022-5347(01)63311-1

1527-3792

Ajay Nehra, Kazem M. Azadzoi, Robert B. Moreland, Ajay Pabby, Mike B. Siroky, Robert J. Krane, Irwin Goldstein, Daniel Udelson,

Urological Disorders and Treatments

No AccessJournal of UrologyInvestigative Urology1 Jun 1998CAVERNOSAL EXPANDABILITY IS AN ERECTILE TISSUE MECHANICAL PROPERTY WHICH PREDICTS TRABECULAR HISTOLOGY IN AN ANIMAL MODEL OF VASCULOGENIC ERECTILE DYSFUNCTION AJAY NEHRA, KAZEM M. AZADZOI, ROBERT B. MORELAND, AJAY PABBY, MIKE B. SIROKY, ROBERT J. KRANE, IRWIN GOLDSTEIN, and DANIEL UDELSON AJAY NEHRAAJAY NEHRA , KAZEM M. AZADZOIKAZEM M. AZADZOI , ROBERT B. MORELANDROBERT B. MORELAND , AJAY PABBYAJAY PABBY , MIKE B. SIROKYMIKE B. SIROKY , ROBERT J. KRANEROBERT J. KRANE , IRWIN GOLDSTEINIRWIN GOLDSTEIN , and DANIEL UDELSONDANIEL UDELSON View All Author Informationhttps://doi.org/10.1016/S0022-5347(01)63311-1AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: Reliable, clinically available, non-invasive measurements able to predict trabecular histology without the need for erectile tissue biopsy would improve impotence management, since the percentage of trabecular smooth muscle content has been shown to be associated with corporal veno-occlusive dysfunction. The purpose was to identify whether the erectile tissue mechanical property, cavernosal expandability, correlated with the percentage of trabecular smooth muscle content in an animal model of hypercholesterolemia and ischemic-induced corporal fibrosis. Materials and Methods: New Zealand White rabbits (6 to 7 months old, 3 to 3.5 kg.), were divided into control (n = 7), hypercholesterolemic (n = 5, 0.5% cholesterol diet) and atherosclerotic groups (n = 8, 0.5% cholesterol diet with balloon de-endothelialization). At 16 weeks, the corpora cavernosa were removed en bloc and submerged in physiologic salt solution, and volume-pressure data were plotted at 20 mm. Hg pressure intervals under trabecular smooth muscle relaxation. Cavernosal expandability, X, (the measure of the ability to achieve high corporal expansion at relatively low intracavernosal pressure) and tunical distensibility, VE/VF, (relative volume of fully erect to flaccid penis) were calculated. Erectile tissue was assessed by computer-assisted color histomorphometry with Masson's trichrome stained sections (30 to 45 high power fields/animal) to assess percentage of trabecular smooth muscle content. Results: The overall mean percentage of trabecular smooth muscle content and mean cavernosal expandability values were 45.4 +/− 1.6, 39.2 +/− 0.9, 33.9 +/− 0.6 and 0.0165 +/− 3.04 × 10−3, 0.0116 +/− 1.63 × 10−3, 0.0118 +/− 1.26 × 10−3 mm. Hg−1 for the control, hypercholesterolemic and atherosclerotic groups, respectively (r = 0.87). Significant differences in trabecular smooth muscle content were observed among all 3 groups, and in cavernosal expandability, between control and atherosclerotic groups, as well as between control and hypercholesterolemic groups but not between atherosclerotic and hypercholesterolemic groups. Conclusions: The erectile tissue mechanical property, cavernosal expandability, correlated with erectile tissue structural quality. 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S1, (26-33), Online publication date: 1-Dec-1998. Volume 159Issue 6June 1998Page: 2229-2236 Advertisement Copyright & Permissions© 1998 by American Urological Association, Inc.MetricsAuthor Information AJAY NEHRA More articles by this author KAZEM M. AZADZOI More articles by this author ROBERT B. MORELAND More articles by this author AJAY PABBY More articles by this author MIKE B. SIROKY More articles by this author ROBERT J. KRANE More articles by this author IRWIN GOLDSTEIN More articles by this author DANIEL UDELSON More articles by this author Expand All Advertisement PDF downloadLoading ...