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BIBTEX RIS

Bleeding reduction after topical application of tranexamic acid together with Betadine solution in total knee arthroplasty. A randomised controlled study

2014; Elsevier BV; Volume: 101; Issue: 1 Linguagem: Inglês

10.1016/j.otsr.2014.10.013

1877-0568

Lúcio Honório de Carvalho, Eduardo Frois Temponi, Luiz Fernando Machado Soares, Matheus Braga Jacques Gonçalves, Lincoln Paiva Costa, M.L. Almeida Tavares de Souza,

Platelet Disorders and Treatments

Topical application of tranexamic acid to the knee joint before closure in total knee arthroplasty reduces postoperative bleeding without increase in complication. However, it is unknown the effectiveness of topic TXA performed with other topical medications, like povidone-iodine solution. One hundred and twenty-five patients were randomized to receive 100 mL of povidone-iodine solution (control: group A) or 1.5 (group B) and 3.0 g (group C) of topical TXA in povidone-iodine solution applied into the knee before closure in total knee arthroplasty. The patients in the TXA groups had higher mean postoperative hemoglobin levels (P = 0.01 and P = 0.03 in groups B and C, respectively) and a reduced postoperative blood loss in the TXA groups (P = 0.07 and P = 0.09 in groups B and C, respectively). No significant complications were observed. In this study, topical application of tranexamic acid after total knee arthroplasty together with povidone-iodine solution results in higher postoperative hemoglobin levels and lower blood loss compared with those in the control group without other complications. I – I: high-powered prospective randomized trial.