Portal de Periódicos da CAPES

New syntheses of pyrazolo[3,4‐d]pyrimidine, pyrazolo[3,4‐d]pyridazine, isoindolinedione and pyrazole derivatives

1989; Wiley; Volume: 331; Issue: 1 Linguagem: Inglês

10.1002/prac.19893310106

0021-8383

Abdou O. Abdelhamid, A. M. NEGM, Ikhlass M. Abbas,

Synthesis and pharmacology of benzodiazepine derivatives

Abstract Phenacylmalononitriles 2 react with hydrazines, acetic‐hydrochloric acid and with diazotised primary aromatic amines to afford phenacylpyrazole ( 5a,b ), aminofurans ( 6a,b ) and aminopyrazole derivatives ( 3a,d ) respectively. The synthesised derivatives ( 3d, 6a ) were the key materials for the synthesis of isoindolinedione, ( 7a – c ) pyrazolopyrimidine ( 9, 10 ), and pyrazolopyridazine derivatives ( 11 ). The structures of the newly synthesised heterocycles were established on the basis of elemental analyses and spectral data besides synthesis via other routes.