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Toxicity in mice of lectin ebulin f present in dwarf Elderberry (Sambucus ebulus L.)

2012; Elsevier BV; Volume: 61; Linguagem: Inglês

10.1016/j.toxicon.2012.10.009

1879-3150

Pilar Jiménez, Manuel J. Gayoso, Jesús Tejero, Patricia Cabrero, Damián Córdoba-Díaz, José E. Basterrechea, Tomás Girbés,

Bioactive Compounds and Antitumor Agents

Dwarf elder fruits (Sambucus ebulus) contain the ribosome-inactivating lectin ebulin f structurally related to ricin. We investigated intraperitoneal toxicity of ebulin f in mice and found that it triggers specific derangement of the intestines. Ebulin f was much less toxic than ricin to mice when administered intraperitoneally. The targets were cells of the intestinal crypts, which underwent apoptosis. Small intestine crypts were more sensitive than large intestine crypts.