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Natural Pregnancies in HIV-Serodiscordant Couples Receiving Successful Antiretroviral Therapy

2006; Lippincott Williams & Wilkins; Volume: 43; Issue: 3 Linguagem: Inglês

10.1097/01.qai.0000243091.40490.fd

1944-7884

Pablo Barreiro, Jorge del Romero, Manuel Leal, Víctoria Hernando, Rom n Asencio, Carmen de Mendoza, Pablo Labarga, Marina N ez, J. T. Ramos, Juan Gonz lez-Lahoz, Vincent Soriano,

HIV Research and Treatment

Summary: Increasing numbers of HIV-serodiscordant heterosexual couples are concerned about the chances for pregnancy. We reviewed all natural pregnancies attained by HIV-serodiscordant couples seen in 3 clinics in Spain, in which the infected partner had undetectable plasma viremia while receiving highly active antiretroviral therapy (HAART). In the case of HIV-infected mothers, only those with undetectable viremia during pregnancy and at delivery were chosen. A total of 62 HIV-serodiscordant couples, 22 HIV-infected women (mean CD4 count of 522 cells/μL, 55% hepatitis C virus [HCV]-seropositive) and 40 HIV-infected men (mean CD4 count of 629 cells/μL, 75% HCV-seropositive), were recorded. Overall, 76 natural pregnancies occurred, and 68 children were born. There were 9 fetal deaths, 1 twin pregnancy, 6 couples with 2 consecutive babies, and 4 couples with 3 consecutive newborns. There were no cases of HIV seroconversion in uninfected sexual partners. One case of vertical HIV transmission occurred, however. Serodiscordant couples attaining natural pregnancy are exposed to a negligible risk of sexual transmission of HIV when the infected partner presents with complete suppression of plasma viremia while receiving HAART.