Application of CR-39 for alpha-autoradiography and in vivo detection of 10B accumulations in tumor bearing mice
1999; Elsevier BV; Volume: 31; Issue: 1-6 Linguagem: Inglês
10.1016/s1350-4487(99)00103-1
ISSN1879-0925
AutoresKoichi Ogura, Hironobu Yanagië, Masazumi Eriguchi, Takuya Matsumoto, Hisao Kobayashi,
Tópico(s)Radiation Therapy and Dosimetry
ResumoIt is required to achieve an accurate measurement of 10B distributions and concentrations in the tumor cells for boron neutron capture therapy (BNCT). We employed a technique of neutron capture autoradiography (NCAR) of the whole body samples of tumor bearing mice using CR-39 plastic track detectors to the measurements of 10B accumulations in mice. In order to confirm the validity of the NCAR measurements, the differential REL spectrum for the neutron-induced particles emitted from the standard filter paper sheets was compared with that for 10B-compound solution. Differential REL spectrum for protons originated from the biogenically abundant nuclides through 14N (n, p)14C and 1H (n, n′) 1H reactions was measured in vivo using a small piece of CR-39 inserted into the tumor of mouse.
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