Portal de Periódicos da CAPES

Amphotericin B Methyl Ester Hydrochloride and Amphotericin B: Comparative Acute Toxicity

1973; American Association for the Advancement of Science; Volume: 179; Issue: 4073 Linguagem: Inglês

10.1126/science.179.4073.584

1095-9203

G. R. Keim, J. W. Poutsiaka, John Kirpan, C. Hans Keysser,

Animal testing and alternatives

In single-dose parenteral studies with mice and dogs, the methyl ester hydrochloride of amphotericin B proved to be significantly less toxic than the parent compound, especially to the kidney.