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Furostanol saponins and quercetin glycosides from the leaves of Helleborus viridis L.

2004; Elsevier BV; Volume: 65; Issue: 21 Linguagem: Inglês

10.1016/j.phytochem.2004.07.013

1873-3700

Alessandra Braca, José M. Prieto, Nunziatina De Tommasi, Franca Tomé, Ivano Morelli,

Natural product bioactivities and synthesis

Phytochemical analysis of the polar extracts of the leaves of Helleborus viridis (Ranunculaceae) resulted in the isolation of two new furostanol saponins (25R)-26-[(α-l-rhamnopyranosyl)oxy]-22α-methoxyfurost-5-en-3β-yl O-β-d-glucopyranosyl-(1 → 3)-O-[6-acetyl-β-d-glucopyranosyl-(1 → 3)]-O-β-d-glucopyranoside (1) and (25R)-26-[(α-l-rhamnopyranosyl)oxy]-22α-methoxyfurost-5-en-3β-yl O-β-d-glucopyranosyl-(1 → 3)-O-β-d-glucopyranosyl-(1 → 3)-O-β-d-glucopyranoside (2) and three new quercetin glycosides, quercetin 3-O-(2-E-caffeoyl)-α-l-arabinopyranosyl-(1 → 2)-β-d-galactopyranoside-7-O-β-d-glucopyranoside (3), quercetin 3-O-(2-E-caffeoyl)-α-l-arabinopyranosyl-(1 → 2)-β-d-galactopyranoside (4), and quercetin 3-O-α-l-arabinopyranosyl-(1 → 2)-β-d-galactopyranoside (5). The structures of the new compounds were determined by spectroscopic analysis, including 2D NMR data and mass spectrometry.