Produção Nacional
Revisado por pares
Relation of admission white blood cell count to long-term outcomes after primary coronary angioplasty for acute myocardial infarction (The Stent PAMI Trial)
2003; Elsevier BV; Volume: 91; Issue: 6 Linguagem: Inglês
10.1016/s0002-9149(02)03416-1
ISSN1879-1913
AutoresGregory G. Pellizzon, Simon Dixon, Gregg W. Stone, David A. Cox, Luiz Alberto Mattos, Judith Boura, Lorelei Grines, Srinivas Addala, William W. O’Neill, Cindy L. Grines,
Tópico(s)Blood properties and coagulation
ResumoThe presence of an elevated white blood cell count (WBC) in patients with acute coronary syndromes identifies a cohort at increased risk for short- and long-term ischemic complications and death. 1 Ross R. Atherosclerosis—an inflammatory disease. N Engl J Med. 1999; 340: 115-126 Crossref PubMed Scopus (19671) Google Scholar , 2 Ridker P.M. Cushman M. Stampfer M.J. Tracy R.P. Hennekens C.H. Inflammation, aspirin, and the risk of cardiovascular disease in apparently healthy men. N Engl J Med. 1997; 336: 973-979 Crossref PubMed Scopus (4982) Google Scholar , 3 Yarnell J.W. Baker I.A. Sweetnam P.M. Bainton D. O'Brien J.R. Whitehead P.J. Elwood P.C. Fibrinogen, viscosity, and white blood cell count are major risk factors for ischemic heart disease The Caerphilly and Speedwell collaborative heart disease studies. Circulation. 1991; 83: 836-844 Crossref PubMed Google Scholar , 4 Burr M.L. Holliday R.M. Fehily A.M. Whitehead P.J. Haematological prognostic indices after myocardial infarction evidence from the Diet and Reinfarction Trial (DART). Eur Heart J. 1992; 13: 166-170 PubMed Google Scholar , 5 Lowe G.D. Machado S.G. Krol W.F. Barton B.A. Forbes C.D. White blood cell count and haematocrit as predictors of coronary recurrence after myocardial infarction. Thromb Haemost. 1985; 54: 700-703 PubMed Google Scholar , 6 Ernst E. Hammerschmidt D.E. Baggae U. Matrai A. Dormandy J.A. Leukocytes and the risk of ischemic diseases. JAMA. 1987; 257: 2318-2324 Crossref PubMed Scopus (528) Google Scholar , 7 Kinlay S. Selwyn A.P. Libby P. Ganz P. Inflammation, the endothelium, and the acute coronary syndromes. J Cardiovasc Pharmacol. 1998; 32: S62-S66 Crossref PubMed Scopus (11) Google Scholar , 8 Cannon C.P. McCabe C.H. Wilcox R.G. Bentley J.H. Braunwald E. Association of white blood cell count with increased mortality in acute myocardial infarction and unstable angina. Am J Cardiol. 2001; 87: 636-639 Abstract Full Text Full Text PDF PubMed Scopus (167) Google Scholar , 9 Furman M.I. Becker R.C. Yarzebski J. Savegeau J. Gore J.M. Goldberg R.J. Effect of elevated leukocyte count on in-hospital mortality following acute myocardial infarction. Am J Cardiol. 1996; 78: 945-948 Abstract Full Text Full Text PDF PubMed Scopus (103) Google Scholar An elevated admission WBC has also been associated with reduced coronary flow, greater thrombus burden, and an increased frequency of short-term complications in patients treated with thrombolytic therapy for acute myocardial infarction (AMI). 10 Barron H.V. Cannon C.P. Murphy S.A. Braunwald E. Gibson C.M. Association between white blood cell count, epicardial blood flow, myocardial perfusion and clinical outcomes in the setting of acute myocardial infarction. A Thrombolysis in Myocardial Infarction 10 Substudy. Circulation. 2000; 102: 2329-2334 Crossref PubMed Scopus (342) Google Scholar No data exist regarding the relation between leukocytosis, baseline characteristics, and angiographic and clinical outcomes in patients treated with primary angioplasty. This study was performed to examine the relation between the admission WBC, demographic and angiographic features, and clinical outcomes for patients with AMI who underwent a mechanical reperfusion strategy.
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