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Identification of a New Circulating Recombinant Form of HIV Type 1, CRF11-cpx, Involving Subtypes A, G, J, and CRF01-AE, in Central Africa

2002; Mary Ann Liebert, Inc.; Volume: 18; Issue: 3 Linguagem: Inglês

10.1089/08892220252781301

1931-8405

Céline Montavon, Laurence Vergne, Anke Bourgeois, Eitel Mpoudi‐Ngolé, Gabriel Malonga-Mouellet, Christelle Butel, Coumba Touré‐Kâne, Éric Delaporte, Martine Peeters,

Hepatitis B Virus Studies

In this study, we characterized three full-length genome sequences with a similar mosaic structure from epidemiologically unlinked individuals from Cameroon (97CM-MP818) and the Central African Republic (99CF-MP1298 and 99CF-MP1307). Phylogenetic and recombinant analysis confirmed that the three strains had a similar complex recombinant genome, which we can designate now as CRF11-cpx. This new CRF was composed of successive fragments of subtype A, G, J, and CRF01-AE. The previously reported GR17 virus from a Greek patient infected in the Democratic Republic of Congo (DRC) has a similar structure and should be considered as the prototype strain of CRF11-cpx. This new CRF circulates in Cameroon, Central African Republic, Gabon, and DRC, although the exact prevalences remain to be determined.