Peripheral and central 5-hydroxytryptamine in trisomy 21
1979; Elsevier BV; Volume: 25; Issue: 23 Linguagem: Inglês
10.1016/0024-3205(79)90606-4
ISSN1879-0631
AutoresJean‐Pierre Ternaux, J. F. Mattéi, M. Faudon, M.C. Barrit, J. P. Ardissone, Françoise Giraud,
Tópico(s)Genomic variations and chromosomal abnormalities
ResumoAbstract Peripheral and central metabolism of 5-hydroxytryptamine was studied in 16 patients with trisomy 21 and compared to that in 4 karyotypically normal mentally retarded children. Serum 5-hydroxytryptamine was markedly decreased in the trisomics whereas cerebrospinal fluid levels of 5-hydroxytryptamine and 5-hydroxyindole acetic acid were increased in the same groups. These results are discussed with respect to regulatory mechanisms of 5-HT metabolism.
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