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TGFBIp/βig-h3 protein: A versatile matrix molecule induced by TGF-β

2007; Elsevier BV; Volume: 39; Issue: 12 Linguagem: Inglês

10.1016/j.biocel.2007.06.004

1878-5875

Narendra Thapa, Byung-Heon Lee, In‐San Kim,

Cellular Mechanics and Interactions

TGFBIp/βig-h3 protein is an extracellular matrix molecule initially cloned from human adenocarcinoma cells treated with TGF-β. Its precise function remains obscure but a number of studies have demonstrated it to be an intriguingly versatile molecule role in a wide range of physiological and pathological conditions. To date, the most extensively studied and reported action of TGFBIp/βig-h3 protein is in corneal dystrophy and several excellent reviews are available on this. Work from various laboratories on this molecule has compiled a tremendous amount of information over the past decade and a half. Here we review the current understanding on TGFBIp/βig-h3 protein and its functions in morphogenesis, extracellular matrix interactions, adhesion/migration, corneal dystrophy, tumorigenesis, angiogenesis, nephropathies, osteogenesis, wound healing and inflammation.