Produção Nacional
Revisado por pares
Anti-HCV antibody is sensitive but not sufficient to detect HCV active infection in renal transplanted patients: The role of PCR for HCV-RNA
1997; Elsevier BV; Volume: 29; Issue: 1-2 Linguagem: Inglês
10.1016/s0041-1345(96)00099-1
ISSN1873-2623
AutoresElias David‐Neto, Khalid A. A. Abdallah, Leda Bassit, Analice N. PEREIRA, Aitor Alquézar, João Fonseca, L E Ianhez, E Sabbaga,
Tópico(s)Alcohol Consumption and Health Effects
ResumoThe prevalence of hepatitis C virus (HCV) infection in the general population and in various high risk groups in south India was assessed. A total of 258 out of 3589 (7.1%) subjects (both general and risk groups) tested positive for HCV RNA by RT-PCR, while the third generation ELISA detected only 6.1% (221/3589). This suggests that a number of cases go unreported, as screening of blood and blood products is done primarily by ELISA. Among 124 chronic renal failure (CRF) patients with a history of renal transplant or haemodialysis, 37% were found to be positive for HCV RNA by RT-PCR. We also found a significantly higher rate of transmission of HCV among people exposed to tattooing (2.8%) and pilgrims (5.8%) (slashing a cultural practice in one sect of Muslims). In addition, our studies also reveal a high prevalence of HCV infection (44%) among patients with Lichen planus. The most prevalent genotype observed in our population was 1b (43.4%) followed by 3b (30.2%). The other genotype 1a was observed in 16.6% of patients followed by 3a observed in 3.4% of the patients. Our findings suggest that HCV may be the major cause of post-transplant hepatitis in Indian patients with CRF and indicate the necessity for stringent screening procedures for these viral infections.
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