Voltar
Artigo Revisado por pares
BIBTEX RIS

Asymmetric Synthesis of Bryostatin 2

1998; Wiley; Volume: 37; Issue: 17 Linguagem: Inglês

10.1002/(sici)1521-3773(19980918)37

ISSN

1521-3773

Autores

David A. Evans, Percy H. Carter, Erick M. Carreira, Joëlle Prunet, André B. Charette, Mark Lautens,

Tópico(s)

Carbohydrate Chemistry and Synthesis

Resumo

The potent bryostatin antitumor agents are currently in phase II clinical trials for the treatment of a variety of forms of cancer. Aldol reactions and directed reductions are among the essential steps for the formation of fragments A–C in the total synthesis of the title compound. Coupling of these fragments by sulfone-based olefination and alkylation reactions was followed by macrocyclization and introduction of the enoate moieties on rings B and C.

Referência(s)