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A broad study of two new promising antimycobacterial drugs: Ag(I) and Au(I) complexes with 2-(2-thienyl)benzothiazole

2012; Elsevier BV; Volume: 38; Issue: 1 Linguagem: Inglês

10.1016/j.poly.2012.03.016

1873-3719

Guilherme Alves Pereira, Antônio Carlos Massabni, E.E. Castellano, Luiz Antônio S. Costa, Clarice Queico Fugimura Leite, Fernando R. Pavan, Alexandre Cuin,

Click Chemistry and Applications

Synthesis, characterization, DFT simulation and biological assays of two new metal complexes of 2-(2-thienyl)benzothiazole – BTT are reported. The complexes [Ag(BTT)2NO3] – AgBTT2 and [Au(BTT)Cl]·½H2O – AuBTT were obtained by mixing the ligand with silver (I) nitrate or gold(I) chloride in methanolic solution. Characterization of the complexes were based on elemental (C, H, N and S), thermal (TG-DTA) analysis, 13C and 1H NMR, FT-IR and UV–Vis spectroscopic measurements, as well as the X-ray structure determination for AgBTT2. Spectroscopic data predicted by DFT calculations were in agreement with the experimental data for both complexes. The ligand BTT was synthesized by the condensation of 2-thiophenecarboxaldehyde and 2-aminothiophenol in a microwave furnace. AgBTT2 has a monomeric structure. Both complexes show a good activity against Mycobacterium tuberculosis. Free BTT shows low antitubercular activity.