A novel κ-opioid receptor agonist, TRK-820, blocks the development of physical dependence on morphine in mice
2000; Elsevier BV; Volume: 66; Issue: 25 Linguagem: Inglês
10.1016/s0024-3205(00)80011-9
ISSN1879-0631
AutoresMinoru Tsuji, Hiroshi Takeda, Teruhiko Matsumiya, Hiroshi Nagase, Mitsuaki Yamazaki, Minoru Narita, Tsutomu Suzuki,
Tópico(s)Pharmacological Receptor Mechanisms and Effects
ResumoThe effects of a novel κ-opioid receptor agonist, TRK-820, on the development of physical dependence on morphine were investigated in mice in comparison with those of U-50, 488H. A marked body weight loss and several withdrawal signs were observed following naloxone challenge in morphine-dependent mice. Co-injection of TRK-820 (0.003–0.03 mg/kg, s.c.) but not U-50,488H (1–10 mg/kg, s.c.) during chronic morphine treatment dose-dependently suppressed the naloxone-precipitated body weight loss, jumping, wet dog shakes and diarrhea. These results suggest that TRK-820-sensitive κ -opioid receptor subtypes may play a significant role in modulating the development of physical dependence on morphine.
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