Deposits of Topical Norfloxacin in the Treatment of Bacterial Keratitis
1997; Lippincott Williams & Wilkins; Volume: 16; Issue: 4 Linguagem: Inglês
10.1097/00003226-199707000-00008
ISSN1536-4798
AutoresAlfredo Castillo, José Manuel Benítez del Castillo, N. Toledano, David Díaz‐Valle, Octavio Sayagues, J. García–Sánchez,
Tópico(s)Antibiotics Pharmacokinetics and Efficacy
ResumoPurpose. Fluoroquinolone solutions are widely used in therapy of bacterial keratitis. These drugs are sate, and their ocular side effects are mild and not serious in nature. The most frequent untoward effect associated with ciprofloxacin therapy has been a white crystalline deposit. This deposit has not been reported after using the other commercially available quinolones, ofloxacin and norfloxacin. Methods. We present three cases of norfloxaein deposits after treatment of bacterial keratitis. Results. In the three cases, the norfloxacin was substituted for another antibiotic effective against the bacteria, and the precipitate spontaneously resolved in all cases within a few days with no untoward ocular effect. Conclusion. Crystalline corneal deposits can develop during topical norfloxaein therapy. The exact factors contributing to the formation are unknown, although the differences in the tear pH/solubility could be involved. Clinicians should be aware of this ocular side effect
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