Studies on benzene mutagenesis. I. The micronucleus test
1980; Birkhäuser; Volume: 36; Issue: 3 Linguagem: Inglês
10.1007/bf01952286
ISSN0014-4754
AutoresM.M. Díaz, Ana Reiser, L Braier, Juan J. Díez,
Tópico(s)DNA and Nucleic Acid Chemistry
ResumoThe mutagenic action of benzene was studied by means of the micronucleus test performed on mice. A linear dose effect relationship was found for the percentage of micronucleated erythrocytes, against the benzene-dose logarithms. A significant dose effect correlation was found either after the standard 30-h experiments or after a prolonged 54-h one. A higher effect was found in the prolonged experiments, suggesting the induction of a delay in the cell cycle by benzene.
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