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BIBTEX RIS

Does REM sleep deprivation induce subsensitivity of presynaptic dopamine or postsynaptic acetylcholine receptors in the rat brain?

1987; Elsevier BV; Volume: 140; Issue: 2 Linguagem: Inglês

10.1016/0014-2999(87)90808-9

ISSN

1879-0712

Autores

Sérgio Tufik, Lanfranco Ranieri Paolo Troncone, Sandra Bráz, Armando Ramos Silva-Filho, Beatrice G. Neumann,

Tópico(s)

Sleep and Wakefulness Research

Resumo

Yawning behavior was used to evaluate the sensitivity of presynaptic dopamine receptors and postsynaptic acetylcholine receptors of normal and REM sleep-deprived (REMSD) rats. The results show a lowering of the dose-response curve obtained with pomorphine and pilocarpine, as well as a shift to the right in the curve obtained with physostigmine. These results suggest that REMSD induced subsensitization of presynaptic dopamine receptors and/or postsynaptic acetylcholine receptors with different characteristics related to the mechanism of action of the cholinomimetic agent employed.

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