Deprotection and cleavage methods for protected peptide resins containing 4-[(diethylphosphono)difluoromethyl]-D,L-phenylalanine residues
1993; Elsevier BV; Volume: 34; Issue: 44 Linguagem: Inglês
10.1016/s0040-4039(00)61591-5
ISSN1873-3581
AutoresAkira Otaka, Terrence R. Burke, Mark S. Smyth, Motoyoshi Nomizu, Peter P. Roller,
Tópico(s)RNA and protein synthesis mechanisms
ResumoEthyl groups on 4-[(diethylphosphono)difluoromethyl]-D,L-phenylalanine are efficiently removed using SN2-type acidic reagents. These methods were utilized for the solid-phase synthesis of SH2-binding peptides containing nonhydrolyzable phosphotyrosyl mimetics.
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