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Rotavirus vaccines: recent developments and future considerations

2007; Nature Portfolio; Volume: 5; Issue: 7 Linguagem: Inglês

10.1038/nrmicro1692

1740-1534

Juana Ángel, M. Franco, Harry B. Greenberg,

Animal Virus Infections Studies

Rotavirus is responsible for >500,000 deaths in children under 5 years of age worldwide annually. Two new vaccines shown to protect against rotavirus gastroenteritis were recently licensed. Angel, Franco and Greenberg review recent advances in our knowledge of the virus, the host immune response to rotavirus infection and the efficacy and safety of the new vaccines. Two new vaccines have recently been shown to be safe and effective in protecting young children against severe rotavirus gastroenteritis. Although both vaccines are now marketed worldwide, it is likely that improvements to these vaccines and/or the development of future generations of rotavirus vaccines will be desirable. This Review addresses recent advances in our knowledge of rotavirus, the host immune response to rotavirus infection and the efficacy and safety of the new vaccines that will be helpful for improving the existing rotavirus vaccines, or developing new rotavirus vaccines in the future.