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Application of mode-of-action considerations in human cancer risk assessment

2008; Elsevier BV; Volume: 180; Issue: 2 Linguagem: Inglês

10.1016/j.toxlet.2008.05.021

1879-3169

Gary M. Williams,

Effects and risks of endocrine disrupting chemicals

The distinction between carcinogens with DNA-reactive and epigenetic modes of action and the application of mode-of-action considerations to risk assessment is reviewed. A bioindicator-based risk assessment strategy is described. This approach involves the use of mechanistic data to establish a "toxicologically insignificant daily intake".