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TGF-β and TNF-α: antagonistic cytokines controlling type I collagen gene expression

2004; Elsevier BV; Volume: 16; Issue: 8 Linguagem: Inglês

10.1016/j.cellsig.2004.02.007

1873-3913

Franck Verrecchia, Alain Mauviel,

Cell Adhesion Molecules Research

The balance between production and degradation of type I collagen plays a critical role in the development and maintenance of organ and tissue integrity. It also represents the most crucial element governing the process of tissue repair. The synthesis of type I collagen gene is highly regulated by different cytokines at the transcriptional level. Especially, transforming growth factor β (TGF-β), a key player in the physiopathology of tissue repair, enhances type I collagen gene expression. In contrast, tumor necrosis factor α (TNF-α), whose matrix-remodelling function is opposite to that of TGF-β, reduces type I collagen gene expression. This review focuses on transcriptional regulation of type I collagen by TGF-β and TNF-α and on the molecular mechanisms that control the antagonistic activity of TNF-α against TGF-β-driven type I collagen gene expression.