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Rhinocerebral Mucormycosis in a Boy With Recurrent Acute Lymphoblastic Leukemia: Long-Term Survival With Systemic Antifungal Treatment

2002; Lippincott Williams & Wilkins; Volume: 24; Issue: 6 Linguagem: Inglês

10.1097/00043426-200208000-00017

1536-3678

Goetz Wehl, Wolfgang Hoegler, Gabriele Kropshofer, Bernhard Meister, Franz‐Martin Fink, Andreas Heitger,

Ocular Infections and Treatments

Rhinocerebral mucormycosis is rare in hematologic malignancies and usually leads to death within weeks. In contrast, chronic rhinocerebral mucormycosis takes a slowly progressive course and has not been reported in hematologic malignancies in children so far. The authors report the long-term survival of a boy with rhinocerebral mucormycosis in a relapse of acute lymphoblastic leukemia after allogeneic cord blood transplantation. The disease started acutely but took a chronic course thereafter. No surgical debridement was performed because of extensive involvement of the sinuses, orbits, and cerebrum. His long-term survival of 15 months is attributed to the long-range administration of liposomal amphotericin B, early neutrophil recovery, and slow progression of the relapsing acute lymphoblastic leukemia.