Fas antigen mRNA induction in postischemic murine brain
1994; Elsevier BV; Volume: 657; Issue: 1-2 Linguagem: Inglês
10.1016/0006-8993(94)90989-x
ISSN1872-6240
AutoresTomohiro Matsuyama, Ryuji Hata, Masafumi Tagaya, Yoshihiro Yamamoto, Taisuke Nakajima, Jun-ichi Furuyama, Akio Wanaka, Minoru Sugita,
Tópico(s)RNA Interference and Gene Delivery
ResumoFas antigen mRNA induction in the brain was examined using a transient global cerebral ischemia model in BALB/C mice. Northern blot analysis revealed little Fas antigen mRNA expression in the brains of sham-operated mice. A marked induction of Fas mRNA expression was detected in the brains of mice 6 h after 30 min of cerebral ischemia. These results suggest a possible apoptotic mechanism for cell death, mediated by the Fas antigen, in postischemic brain.
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