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Percutaneous Testis Biopsy: An Alternative to Open Testicular Biopsy in the Evaluation of the Subfertile Man

1996; Lippincott Williams & Wilkins; Volume: 156; Issue: 5 Linguagem: Inglês

10.1016/s0022-5347(01)65473-9

1527-3792

Thomas G. Harrington, Donald Schauer, Bruce R. Gilbert,

Sperm and Testicular Function

No AccessJournal of UrologyClinical Urology: Original Article1 Nov 1996Percutaneous Testis Biopsy: An Alternative to Open Testicular Biopsy in the Evaluation of the Subfertile Man Thomas G. Harrington, Donald Schauer, and Bruce R. Gilbert Thomas G. HarringtonThomas G. Harrington , Donald SchauerDonald Schauer , and Bruce R. GilbertBruce R. Gilbert View All Author Informationhttps://doi.org/10.1016/S0022-5347(01)65473-9AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: We evaluated the safety and efficacy of percutaneous testis biopsy by comparing the ultrasound appearance and histological status of testicular parenchyma obtained to those noted after open testis biopsy. Materials and Methods: A total of 51 consecutive infertile men with azoospermia or severely impaired semen quality, in whom ductal obstruction was suspected, underwent percutaneous (31) or open (20) testis biopsy, with 58 and 34 procedures performed, respectively. Scrotal ultrasound was performed preoperatively, and at 2 weeks and 1, 3 and 6 months after biopsy. In addition, immunoglobulins G and A antisperm antibody assays were obtained preoperatively and postoperatively. Two biopsy specimens were obtained from each testis for formal histological evaluation. A touch preparation was also performed and examined immediately for mature spermatozoa using phase contrast microscopy. Results: All biopsies yielded adequate tissue for diagnosis and morphometric analysis. Of 58 percutaneous biopsies 4 (7 percent) demonstrated sonographic evidence of intratesticular bleeding, characterized by a hypoechoic region within the testicular parenchyma, which resolved by 6 months postoperatively. In contrast, 10 of 34 open biopsies (29 percent) showed evidence of intratesticular bleeding or a new area of increased echogenicity at 1 month after the procedure (intraparenchymatous scar). All intraparenchymatous scars persisted to 6 months postoperatively. No patient undergoing percutaneous or open testis biopsy had antisperm antibodies in the seminal fluid or serum (azoospermia cases) or on sperm postoperatively. Of the 32 and 20 patients undergoing percutaneous and open testis biopsy 3 (9 percent) and 14 (70 percent), respectively, required narcotic analgesia. All patients returned to routine activities within 24 hours after percutaneous testis biopsy. No postoperative infections or extratesticular hematomas were noted. Pathological study was diagnostic in all specimens. Conclusions: Percutaneous testis biopsy is well tolerated by the patient, with fewer apparent complications than and diagnostic value equal to open testis biopsy. 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J. Urol., part 21996; 155: 364A. abstract 213. Google Scholar 17 : Sperm retrieval from testis biopsy with fertilization and pregnancy following ICSI. San Francisco: Pacific Coast Fertility Society1996: A2. Google Scholar 18 : The effect of testis biopsy on autosensitization against spermatozoal antigens. Clin. Exp. Immunol.1974; 18: 201. Google Scholar Department of Urology, State University of New York at Stony Brook, Stony Brook, New York.© 1996 by American Urological Association, Inc.FiguresReferencesRelatedDetailsCited by (2018) EDITORIAL COMMENTJournal of Urology, VOL. 163, NO. 6, (1715-1716), Online publication date: 1-Jun-2000.DARDASHTI K, WILLIAMS R and GOLDSTEIN M (2018) MICROSURGICAL TESTIS BIOPSY: A NOVEL TECHNIQUE FOR RETRIEVAL OF TESTICULAR TISSUEJournal of Urology, VOL. 163, NO. 4, (1206-1207), Online publication date: 1-Apr-2000.Levine L and Lisek E (2018) SUCCESSFUL SPERM RETRIEVAL BY PERCUTANEOUS EPIDIDYMAL AND TESTICULAR SPERM ASPIRATIONJournal of Urology, VOL. 159, NO. 2, (437-440), Online publication date: 1-Feb-1998. Volume 156Issue 5November 1996Page: 1647-1651 Advertisement Copyright & Permissions© 1996 by American Urological Association, Inc.MetricsAuthor Information Thomas G. Harrington More articles by this author Donald Schauer More articles by this author Bruce R. 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