Response of Tribolium castaneum (Coleoptera, Tenebrionidae) to Salpichroa origanifolia Withanolides
2001; American Chemical Society; Volume: 50; Issue: 1 Linguagem: Inglês
10.1021/jf010766y
ISSN1520-5118
AutoresGraciela Mareggiani, María Inés Picollo, Adriana S. Veleiro, M. Cristina Tettamanzi, Miriam O. V. Benedetti-Doctorovich, Gerardo Burton, Eduardo Zerba,
Tópico(s)Pharmacological Effects of Medicinal Plants
ResumoBiological effects on Tribolium castaneum larvae were evaluated for three withanolides isolated from Salpichroa origanifolia (Solanaceae), (20S,22R,24S,25S,26R)-5α,6α:22,26:24,25-triepoxy-26-hydroxy-17(13→18)-abeo-ergosta-2,13,15,17-tetraen-1-one (salpichrolide A, 1), (20S,22R,24S,25S,26R)-22,26:24,25-diepoxy-5α,6β,26-trihydroxy-17(13→18)-abeo-ergosta-2,13,15,17-tetraen-1-one (salpichrolide C, 2), and (20S,22R,24S,25S,26R)-5α,6α:22,26:24,25-triepoxy-15,26-dihydroxy-17(13→18)-abeo-ergosta-2,13,15,17-tetraen-1-one (salpichrolide G, 3), and for several chemically modified analogues. The compounds were incorporated into the larval diet at concentrations of 500 and 2000 ppm. Salpichrolide C (2) produced a significant delay in the development of neonate larvae to adults at the highest concentration (2000 ppm); development delays and lethal effects were produced by salpichrolides A (1) and G (3) at both concentrations assayed. The size of surviving adults was used as a criterion for assessing feedant deterrent effects; the results suggest that these compounds act as feeding inhibitors. Influence of chemical modifications in development delay was analyzed. Keywords: Salpichroa origanifolia; withanolides; natural insecticides; Tribolium castaneum; feeding deterrents
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