The ins and outs of leptin receptor activation
2003; Wiley; Volume: 546; Issue: 1 Linguagem: Inglês
10.1016/s0014-5793(03)00440-x
ISSN1873-3468
AutoresLennart Zabeau, Delphine Lavens, Frank Peelman, Sven Eyckerman, Joël Vandekerckhove, Jan Tavernier,
Tópico(s)Adipose Tissue and Metabolism
ResumoThe adipocyte‐derived hormone leptin signals the status of body energy stores by activating its receptor in hypothalamic nuclei. In contrast to the initial expectations, leptin treatment of human obesity was largely unsuccessful. One explanation for this is the marked leptin resistance, which likely operates in part at the receptor level. The leptin receptor is a member of the class I cytokine receptor family, which uses the Janus kinase/signal transducer and activator of transcription pathway as a major signaling route. In this review, we focus on the molecular mechanisms underlying leptin receptor activation. Different modes of leptin‐induced clustering of the ectodomains and the subsequent signaling events will be discussed.
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