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Proteinuria following Renal Transplantation

1977; Karger Publishers; Volume: 18; Issue: 1 Linguagem: Inglês

10.1159/000180766

1423-0186

Kapil D. Sethi, Matthew R. First, A. J. Pesce, James P. Fidler, Victor E. Pollak,

Organ Transplantation Techniques and Outcomes

Proteinuria was studied in ten renal allograft recipients; it was defined as: (a) glomerular – characterized by predominant albumin excretion; (b) tubular – significant excretion of both albumin and low molecular weight (LMW) proteins; and (c) glomerulo-tubular or mixed type, a combination of the two. LMW protein and albumin were quantitated by polyacrylamide gel electrophoresis with sodium dodecyl sulfate. In the immediate posttransplant period, LMW protein and albumin excretion, expressed as a percentage of creatinine clearance, were high, revealing a mixed pattern, and excretion of both protein classes was higher than during both acute tubular necrosis and acute rejection crisis. Tubular proteinuria was observed in acute tubular necrosis; a glomerulo-tubular or mixed pattern of protein excretion in acute rejection crises.