Portal de Periódicos da CAPES

Plasma-Cell Dyscrasia and Peripheral Neuropathy with a Monoclonal Antibody to Peripheral-Nerve Myelin

1980; Massachusetts Medical Society; Volume: 303; Issue: 11 Linguagem: Inglês

10.1056/nejm198009113031105

1533-4406

Norman Latov, William H. Sherman, Raffaello Nemni, Giuliana Galassi, Joanna S. Shyong, Audrey S. Penn, Leonard Chess, Marcelo R. Olarte, Lewis P. Rowland, Elliott F. Osserman,

Multiple Myeloma Research and Treatments

PERIPHERAL neuropathy has been associated with plasma-cell dyscrasia, 1 but it is not known whether the monoclonal immunoglobulins react with peripheral-nerve antigens. We report on a patient with a peripheral neuropathy associated with an IgMk monoclonal protein, in whom pathological and immunological studies indicated that the IgMk antibody was directed against peripheral-nerve myelin, as shown by complement fixation and immunoabsorption.Case ReportThe patient was a 45-year-old man admitted for evaluation of a slowly progressive sensory-motor neuropathy of 11 years' duration. On examination there was moderate to severe weakness and atrophy of the muscles of the hands and distal parts of . . .