Novel ethyl-5-amino-3-methylthio-1H-pyrazole-4-carboxylates: Synthesis and pharmacological activity
2012; Elsevier BV; Volume: 20; Issue: 3 Linguagem: Inglês
10.1016/j.jscs.2012.06.011
ISSN2212-4640
AutoresShivaji N. Thore, Sunil Gupta, Kamalkishor G. Baheti,
Tópico(s)Multicomponent Synthesis of Heterocycles
ResumoA series of novel ethyl-5-amino-3-methylthio-1H-pyrazole-4-carboxylates 3a–j were synthesized from condensation of various hydrazides 2a–j with ketene dithioacetal. The synthesized compounds were screened for in vivo analgesic and anti-inflammatory activities using acetic acid writhing test in mice and carrageenan-induced paw edema test in rat, respectively. Diclofenac sodium was used as a standard drug for comparison. Compounds 3a, 3c and 3d exhibited significant analgesic and anti-inflammatory activities at a dose of 25 mg/kg and showed quite less ulcerogenic index in the range of 0.9–1.12 whereas diclofenac sodium showed 3.10.
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