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Dynamics of Steroid Biosynthesis during the Luteal Placental Shift in Rhesus Monkeys*

1989; Oxford University Press; Volume: 69; Issue: 2 Linguagem: Inglês

10.1210/jcem-69-2-348

1945-7197

William E. Ellinwood, Frank Z. Stanczyk, J Lazúr, MILES J. NOVY,

Reproductive Physiology in Livestock

We studied the dynamics of steroid secretion during the luteal-placental shift of early pregnancy in rhesus monkeys. Daily blood samples were obtained from six pregnant rhesus monkeys during the cycle of conception and for the first 44 days of pregnancy to examine the relationships among aromatizable androgens, estrogens, progesterone (P), and CG in the peripheral circulation. To elucidate the biosynthetic mechanisms involved in the changes in hormonal patterns, minces of placentae and corpora lutea (CL) were incubated in vitro with [3H]pregnenolone ([3H]P5) and [3H]androstenedione ([3H]A), and steroid metabolites were isolated and identified by reverse isotope dilution.