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Specific Inhibition of Nuclear RNA Polymerase II by α-Amanitin

1970; American Association for the Advancement of Science; Volume: 170; Issue: 3956 Linguagem: Inglês

10.1126/science.170.3956.447

1095-9203

Thomas J. Lindell, Fanyela Weinberg, Paul W. Morris, Robert G. Roeder, William J. Rutter,

Healthcare and Venom Research

alpha-Amanitin, a toxic substance from the mushroom Amanita phalloides, is a potent inhibitor of DNA-dependent RNA polymerase II (the nucleoplasmic form) from sea urchin, rat liver, and calf thymus. This compound exerts no effect on the activity of polymerase I (nucleolar form) or polymerase III (also nucleoplasmic). The inhibition is due to a specific interaction with polymerase II or with a complex of DNA and polymerase II.