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Synthesis of vitamin D5: Its biological activity relative to vitamins D3 and D2

1979; Elsevier BV; Volume: 197; Issue: 1 Linguagem: Inglês

10.1016/0003-9861(79)90226-1

1096-0384

Joseph L. Napoli, Mary A. Fivizzani, Heinrich K. Schnoes, Hector F. DeLuca,

Vitamin K Research Studies

The chemical synthesis, spectral characterization, and biological activity of vitamin D5 in vitamin D-deficient rats is reported. Vitamin D5 is about 180-fold less active than vitamin D3 in calcification of rachitic cartilage and about 100- to 200-fold less active in induction of bone-calcium mobilization. In stimulation of intestinal-calcium transport, vitamin D5 is about 80-fold less active than vitamin D3. Vitamins D2 and D3 appear to be equiactive in all three responses when low doses are administered.