Portal de Periódicos da CAPES

Ordinary Differential Equation PK/PD Models Using the SAS Macro NLINMIX

2004; Taylor & Francis; Volume: 14; Issue: 2 Linguagem: Inglês

10.1081/bip-120037194

1520-5711

Andrzej T. Gałecki, Russell D. Wolfinger, Óscar Linares, Marla J. Smith, Jeffrey B. Halter,

Statistical Methods and Inference

We describe some theory and recent enhancements for the SAS macro NLINMIX (Wolfinger, R. D. (1993). Laplace's approximation for nonlinear mixed effects models. Biometrika 80:791-795) that enable model calculation to take place within the interaction matrix language SAS/IML (SAS Institute Inc. (1999a). SAS/IML User's Guide Version 7. Cary, NC: SAS Institute Inc.). They provide greater flexibility and scope for the specification and analysis of complex nonlinear mixed models. For example, using data from a frequently sampled intravenous glucose test, we fit a two-compartment kinetics model that has no closed-form representation. It is derived as the solution of a system of ordinary differential equations and specified as such in SAS/IML. Additional details and example NLINMIX code are available in Appendix A.