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Revisão Revisado por pares
BIBTEX RIS

Opioid Tolerance and Hyperalgesia

2007; Elsevier BV; Volume: 91; Issue: 2 Linguagem: Inglês

10.1016/j.mcna.2006.10.003

ISSN

1557-9859

Autores

Grace Chang, Lucy Chen, Jianren Mao,

Tópico(s)

Pain Management and Placebo Effect

Resumo

Opioids have been successfully used for the management of acute and cancer-related pain. Concerns regarding side effects, tolerance, dependence, addiction, and hyperalgesia have limited the use of opioids for the management of chronic nonmalignant pain. This article will review updated information from both clinical and preclinical studies regarding opioid-induced hyperalgesia, tolerance, and dependence. The implications of these issues in clinical opioid therapy also will be discussed.

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