Portal de Periódicos da CAPES

The chemical and biological properties of methoxyfenozide, a new insecticidal ecdysteroid agonist

2001; Wiley; Volume: 57; Issue: 2 Linguagem: Inglês

10.1002/1526-4998(200102)57

1526-4998

Glenn R. Carlson, Tarlochan S. Dhadialla, Ricky Hunter, Richard K. Jansson, C S Jany, Zev Lidert, Richard A. Slawecki,

Insect Pheromone Research and Control

Methoxyfenozide [N-tert-butyl-N ′-(3-methoxy-o-toluoyl)-3,5-xylohydrazide; RH-2485] is the newest diacylhydrazine insecticide to reach the marketplace. It binds with very high affinity to the ecdysone receptor complex (EcR:USP) in lepidopteran insects [Kd = 0.5 nM (Plodia)], where it functions as a potent agonist, or mimic, of the insect molting hormone, 20-hydroxyecdysone (20E). Methoxyfenozide exhibits high insecticidal efficacy against a wide range of important caterpillar pests, including many members of the family Pyralidae, Pieridae, Tortricidae and Noctuidae. It is most effective when ingested by the target caterpillar, but it also has some topical and ovicidal properties. It is modestly root systemic, but not significantly leaf-systemic. Evidence collected to date indicates that methoxyfenozide has an excellent margin of safety to non-target organisms, including a wide range of non-target and beneficial insects. © 2001 Society of Chemical Industry