Ketoconazole Shampoo: Effect of Long-Term Use in Androgenic Alopecia
1998; Karger Publishers; Volume: 196; Issue: 4 Linguagem: Inglês
10.1159/000017954
ISSN1421-9832
AutoresC Piérard-Franchimont, Piet De Doncker, G. Cauwenbergh, Gérald Pierard,
Tópico(s)Dermatology and Skin Diseases
Resumo<b>Background:</b> The pathogenesis of androgenic alopecia is not fully understood. A microbial-driven inflammatory reaction abutting on the hair follicles might participate in the hair status anomaly. <b>Objective:</b> The aim of our study was to determine if ketoconazole (KCZ) which is active against the scalp microflora and shows some intrinsic anti-inflammatory activity might improve alopecia. <b>Method:</b> The effect of 2% KCZ shampoo was compared to that of an unmedicated shampoo used in combination with or without 2% minoxidil therapy. <b>Results:</b> Hair density and size and proportion of anagen follicles were improved almost similarly by both KCZ and minoxidil regimens. The sebum casual level appeared to be decreased by KCZ. <b>Conclusion:</b> Comparative data suggest that there may be a significant action of KCZ upon the course of androgenic alopecia and that <i>Malassezia </i>spp. may play a role in the inflammatory reaction. The clinical significance of the results awaits further controlled study in a larger group of subjects.
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