The determination of levofloxacin by flow injection analysis using UV detection, potentiometry, and conductometry in pharmaceutical preparations
2002; Elsevier BV; Volume: 30; Issue: 3 Linguagem: Inglês
10.1016/s0731-7085(02)00354-0
ISSN1873-264X
AutoresGöksel Altıokka, Zeki Atkoşar, Nafiz Öncü Can,
Tópico(s)Microfluidic and Capillary Electrophoresis Applications
ResumoA flow injection analysis (FIA) using UV detection, potentiometry and conductometry for levofloxacin (LVF) are described in this study. The best solvent system was found to consist of 0.2 M acetate buffer at pH 3 having 10% MeOH. A flow rate of 1 ml min−1 was pumped and active material was detected at 288 nm. The detection limit (LOD) and limit of quantification (LOQ) for FIA were calculated to be 3×10−7 M (S/N=3) and 1×10−7 M (S/N=10), respectively. In the analysis of tablets, the RSD values were found to be 0.83, 0.98 and 0.99 for FIA, potentiometric and conductometric methods, respectively.
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