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Topical anti-inflammatory activity of Serjania erecta Radlk (Sapindaceae) extracts

2008; Elsevier BV; Volume: 118; Issue: 2 Linguagem: Inglês

10.1016/j.jep.2008.03.017

1872-7573

Franciane Gomig, Evelise Fernandes Pietrovski, Alessandro Guedes, Eduardo Monguilhott Dalmarco, Mirele Titton Calderari, Cláudio L. Guimarães, Rafael Mota Pinheiro, Daniela Almeida Cabrini, Michel Fleith Otuki,

Plant Toxicity and Pharmacological Properties

Serjania erecta Radlk (Sapindaceae), commonly called cinco-folhas or cipó-cinco-folhas in Brazil, is thought to be effective for treating several inflammatory diseases. In order to verify the topical anti-inflammatory effect of Serjania erecta, hydroalcoholic extract and fractions were obtained by extraction in solvents of increasing polarity and were tested in mouse models using croton-oil-induced inflammation. Our findings showed that topical application of Serjania erecta hydroalcoholic extract (0.01–3.0 mg/ear), and the dichloromethane (0.03–1.0 mg/ear), ethyl acetate (0.03–1.0 mg/ear), and hexane (0.003–1.0 mg/ear) fractions revealed significant activity, causing a dose-dependent reduction of croton-oil ear edema (ID50 = 0.14 mg/ear, 0.23 mg/ear, 0.14 mg/ear, 0.04 mg/ear, respectively). The extract and all tested fractions also decreased tissue myeloperoxidase activity (indicative of polymorphonuclear leukocytes influx) in mouse-ears treated with croton oil with a maximum inhibition of 72% at 3.0 mg/ear for the hydroalcoholic extract and 81%, 78%, and 83% at 1.0 mg/ear for dichloromethane, ethyl acetate and hexane fractions, respectively. As expected, dexamethasone (0.05 mg/ear) was effective in inhibiting both edema and myeloperoxidase activity (99% and 82%, respectively). In conclusion, our results indicate a topical anti-inflammatory effect for the species of Serjania studied.