Antimicrobial Activity of a Compound Isolated from an Oil-Macerated Garlic Extract
1998; Oxford University Press; Volume: 62; Issue: 5 Linguagem: Inglês
10.1271/bbb.62.1014
ISSN1347-6947
AutoresHisae YOSHIDA, Nami Iwata, Hirotaka Katsuzaki, Rie Naganawa, Keiko Ishikawa, Hiroyuki Fukuda, Tsuchiyoshi Fujino, Atsushi Suzuki,
Tópico(s)Fungal Plant Pathogen Control
ResumoA compound showing antimicrobial activity was isolated from an oil-macerated garlic extract by silica gel column chromatography and preparative TLC. On basis of the results of NMR and MS analyses, it was identified as Z-4,5,9-trithiadeca-1,6-diene-9-oxide (Z-10-devinylajoene; Z-10-DA). Z-10-DA exhibited a broad spectrum of antimicrobial activity against such microorganisms as gram-positive and gram-negative bacteria and yeasts. The antimicrobial activity of Z-10-DA was comparable to that of Z-ajoene, but was superior to that of E-ajoene. Z-10-DA and Z-ajoene are different in respect of substitution of the allyl group by the methyl group flanking a sulfinyl group. This result suggests that substitution by the methyl group would also be effective for the inhibition of microbial growth.
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