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A radiographic, histological, and histometric study of endodontic materials

1989; Elsevier BV; Volume: 15; Issue: 1 Linguagem: Inglês

10.1016/s0099-2399(89)80090-1

1878-3554

María B. Guglielmotti, Osvaldo Zmener, R. L. Cabrini,

Dental Radiography and Imaging

Silicone tubes filled with CRCS, a calcium hydroxide-based cement, were implanted at two different localizations in the right tibias of white male Wistar rats. A similar number of solid silicone rods were implanted in the left tibias of the same animals and were used as inert controls. Fifteen days after implantation the bone tissue reactions to these materials were evaluated by means of radiographic, histological, and histometric methods. The radiographic and histometric analysis of the tissues around the deep end of the implants showed that the amount of reactional bone formation in contact with CRCS was significantly lower than that observed in contact with the controls (p<0.01). Also, the cell counts obtained from the tissues in contact with CRCS were significantly less than those obtained from the controls (p<0.01). This methodology appears to be a refined procedure for analyzing the possible toxic effects of endodontic materials in bone tissues. However, we feel that more extensive experiments will be necessary before predicting the long-term results which could be obtained from this experimental model. Silicone tubes filled with CRCS, a calcium hydroxide-based cement, were implanted at two different localizations in the right tibias of white male Wistar rats. A similar number of solid silicone rods were implanted in the left tibias of the same animals and were used as inert controls. Fifteen days after implantation the bone tissue reactions to these materials were evaluated by means of radiographic, histological, and histometric methods. The radiographic and histometric analysis of the tissues around the deep end of the implants showed that the amount of reactional bone formation in contact with CRCS was significantly lower than that observed in contact with the controls (p<0.01). Also, the cell counts obtained from the tissues in contact with CRCS were significantly less than those obtained from the controls (p<0.01). This methodology appears to be a refined procedure for analyzing the possible toxic effects of endodontic materials in bone tissues. However, we feel that more extensive experiments will be necessary before predicting the long-term results which could be obtained from this experimental model.