Alterations in the concentration of serotonergic and dopaminergic substances in the cerebrospinal fluid of patients with Parkinson's disease, and their changes after l-dopa administration
1993; Elsevier BV; Volume: 159; Issue: 1-2 Linguagem: Inglês
10.1016/0304-3940(93)90817-5
ISSN1872-7972
AutoresHideo Tohgi, Takashi Abe, Satoshi Takahashi, Junko Takahashi, Humitoshi Hamato,
Tópico(s)Neurotransmitter Receptor Influence on Behavior
ResumoIn untreated patients with Parkinson's disease (PD), the total (free and conjugated) serotonin (5-HT) and dopamine (DA) concentrations in the cerebrospinal fluid decreased significantly. While the 5-HT concentration displayed a non-significant trend of negative correlation with the DA concentration in controls, it had a significant positive correlation with the DA concentration in untreated PD patients. In l-dopa-treated patients, the DA concentration increased remarkably, whereas the 5-HT concentration decreased further compared with untreated patients. The tryptophan, 5-hydroxyindolacetic acid (5-HIAA), and 3-OH kynurenine concentrations had significant positive correlations with l-dopa doses. The 5-HT concentration had a significant positive correlation with scores of psychomatric testing in l-dopa-treated patients.
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