Microscopic Polyangiitis Associated with Diffuse Panbronchiolitis
2004; The Japanese Society of Internal Medicine; Volume: 43; Issue: 4 Linguagem: Inglês
10.2169/internalmedicine.43.331
ISSN1349-7235
AutoresPark Jangchul, Shogo Banno, Yoshiki Sugiura, Kosho Yoshikawa, Taio Naniwa, Kaori Wakita, Yoshihito Hayami, Shigeki Sato, Ryuzo Ueda,
Tópico(s)Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
ResumoThere are several case reports of systemic vasculitis associated with chronic suppurative lung diseases. We describe a 46-year-old female, previously diagnosed as having diffuse panbronchiolitis (DPB), presenting with hemosputum and dyspnea. Her serum titer of MPO-ANCA was positive together with a high titer of BPI-ANCA. Chest X-ray and chest CT scan showed pulmonary hemorrhage, and the renal biopsy specimen revealed necrotizing, crescentic glomerulonephritis. She was diagnosed as having ANCA-associated vasculitis, and more specifically, microscopic polyangiitis accompanied by DPB. She was treated with methylprednisolone pulse therapy, followed by intravenous cyclophosphamide. This case suggested a possible association with chronic bacterial infection, which may play a role in the pathogenesis of ANCA-associated vasculitis.
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