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Liquid forms of pharmaceutical co-crystals: exploring the boundaries of salt formation

2010; Royal Society of Chemistry; Volume: 47; Issue: 8 Linguagem: Inglês

10.1039/c0cc04485g

1364-548X

Katharina Bica, Julia L. Shamshina, Whitney L. Hough, Douglas R. MacFarlane, Robin D. Rogers,

Chemical and Physical Properties in Aqueous Solutions

We present evidence of hydrogen bond formation, not salt formation, as the driving force in the liquefaction of a solid pharmaceutical in the form of a neutral acid-base complex, as exemplified by the liquid formed from a mixture of the local anesthetic lidocaine with fatty acids; these complexes exist at the boundary between simple eutectics and partially ionised ionic liquids.