Possible role of brain serotonin in the central effects of ketamine
1978; Elsevier BV; Volume: 17; Issue: 6 Linguagem: Inglês
10.1016/0028-3908(78)90014-x
ISSN1873-7064
AutoresL Vargiu, E. Stefanini, C Musinu, G Saba,
Tópico(s)Tryptophan and brain disorders
ResumoKetamine increased serotonin turnover in the rat brain. This effect persisted for several hours after the anaesthetic effect of ketamine had terminated. Pretreatment with para-chlorophenyl-alanine, an inhibitor of serotonin synthesis, or with methergoline, a serotonin receptor blocker, potentiated the anaesthetic and analgesic effect of ketamine.
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