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BIBTEX RIS

Synthesis and activity of 1-N-iminosugar inhibitors, siastatin B analogues for α-N-acetylgalactosaminidase and β-N-acetylglucosaminidase

1996; Elsevier BV; Volume: 4; Issue: 1 Linguagem: Inglês

10.1016/0968-0896(95)00166-2

ISSN

1464-3391

Autores

Yoshio Nishimura, Takahiko Satoh, Toshiaki Kudo, Shinichi Kondo, TOMIO TAKEUCHI,

Tópico(s)

Studies on Chitinases and Chitosanases

Resumo

N-Acetylgalactosamine-based 1-N-iminosugars, new types of glycosidase inhibitor have been synthesized by modeling on siastatin B, isolated from a Streptomyces culture. The analogues of siastatin B were proved to be potent inhibitors for alpha-N-acetylgalactosaminidase and/or beta-N-acetylglucosaminidase.

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