Amino acid based bioanalogous polymers. Novel regular poly(ester urethane)s and poly(ester urea)s based on bis( L ‐phenylalanine) α,ω‐alkylene diesters
1997; Wiley; Volume: 198; Issue: 6 Linguagem: Inglês
10.1002/macp.1997.021980620
ISSN1521-3935
AutoresTamara Kartvelishvili, George Tsitlanadze, Lamara Edilashvili, Nona N. Japaridze, Ramaz Katsarava,
Tópico(s)Chemical Synthesis and Analysis
ResumoAbstract Novel biodegradable regular poly(ester urethane)s 2 (η red ≤ 0,62 dL/g) were synthesized for the first time by polycondensation of di‐ p ‐toluenesulfonic acid salts of bis(phenylalanine) α,ω‐alkylene diesters 1 with di‐ p ‐nitrophenyl trimethylenedicarbonate (4) under mild conditions in organic solvents in the presence of triethylamine as acid acceptor. The first synthesis of homopoly(ester urea)s 3 (η red ≤ 0,33 dL/g) was carried out by polycondensation of 1 with di‐ p ‐nitrophenyl carbonate (5) under the same conditions. Preliminary in vitro evaluation of specific and nonspecific hydrolysis of the polymers obtained has been brought about using potentiometric titration.
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