Effect of α‐ and β‐receptor active drugs on corneal thickness
1985; Wiley; Volume: 63; Issue: 3 Linguagem: Inglês
10.1111/j.1755-3768.1985.tb06819.x
ISSN1755-3768
AutoresC. B. Nielsen, Per Julius Nielsen,
Tópico(s)Ocular Surface and Contact Lens
ResumoAbstract Phenylephrine (10mg/ml), phentolamine (10 mg/ml), isoprenaline (0.5 mg/ml) and timolol (5 mg/ ml) were applied topically to one eye of volunteers with normal corneas, the other eye serving as a control. One drop of each drug was given twice a day for 3 or 4 days. Timol was fond to increase corneal thickness in both the midicated and the control eye. A significantly greater effect was noted on the eye receiving the drug directly. When isoprenaline was given for 3 days, a slight significant decrease in corneal thickness was found in both the medicated and the control eye, with the two eyes exhibiting a similar CCT change. The present results are suggestive of endothelial β‐receptor importance in the regulation of corneal thickness.
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